About the Project
This project is one of a number that are in competition for funding from the Red-ALERT CDT, hosted by Bangor University for entry in September 2025.
Overview of the Research:
Bangor University and UKCEH is seeking an ambitious PhD candidate for a cutting-edge research project investigating the spatial and temporal dynamics of antimicrobial resistant (AMR) organisms in freshwater ecosystems. This fully-funded position offers a unique opportunity to contribute to our understanding of the “silent pandemic” of AMR and its environmental transmission.
AMR is a growing threat to both environmental and human health, with freshwater ecosystems serving as critical vectors for AMR transmission. This PhD project aims to unravel the complex dynamics of AMR organisms, with a particular focus on carbapenemase-producing organisms (CPOs). The PhD addresses four key objectives:
(1) Investigate temporal dynamics of AMR inputs from wastewater discharge points to quantify AMR organism loads, providing insights into the impact of wastewater treatment processes on AMR dissemination; (2) Evaluate the culturability of organisms in wastewater treatment plants to assess their viability. This will contribute to our understanding of potential human infection risks; (3) Analyse spatial patterns of AMR prevalence and diversity along river continuums, mapping the distribution and diversity of resistant organisms throughout the river system, and (4) Quantify AMR organism turnover in water columns and river sediments to identify potential reservoirs and hotspots for AMR persistence, crucial for developing targeted mitigation strategies.
This interdisciplinary project bridges microbiology, environmental science, molecular biology, and geospatial analysis. The student will gain expertise in advanced molecular techniques, including cell integrity-qPCR assays for accurate quantification of viable AMR organisms and environmental sampling methodologies across diverse aquatic environments. It will also include training in mesocosm experimental design to simulate river conditions and study AMR organism behaviour and data analysis specific to AMR research, integrating molecular data with environmental parameters
The research aligns with the Red-ALERT CDT vision, addressing critical issues of AMR in freshwater environments and contributing to real-time monitoring and management systems. It directly tackles the Conwy Living Lab challenge by investigating AMR organisms as a crucial component of microbial pollution, with implications for water-based recreation and shellfish consumption risks.
This project offers you the chance to be at the forefront of environmental AMR research, contributing to local and national antimicrobial stewardship efforts and supporting the One Health approach to global health challenges.
Project Keywords: One Health, Antimicrobial Resistance (AMR), Environmental microbiology, Human pathogens, Water quality, Pollution, Public health.
Industrial Partner:
Verily Life Sciences is the industrial partner on this project.
Candidate Requirements:
Applicants should hold, or expect to receive, a First Class or good Upper Second-Class UK Honours degree (or the equivalent) in a relevant subject. A master’s level qualification would also be advantageous.
o Strong background in at least one of the following: microbiology, environmental science, molecular biology, biochemistry, biomedical science.
o Demonstrable experience with laboratory techniques, particularly in microbiology or molecular biology
o Excellent written and verbal communication skills in English
o Master’s degree in a relevant field
o Experience with environmental sampling and fieldwork
o Familiarity with molecular techniques, particularly PCR
o Knowledge of antimicrobial resistance or other emerging contaminants
o Strong motivation and ability to work independently
o Excellent problem-solving and critical thinking skills
o Ability to work effectively in interdisciplinary teams
o Willingness to conduct fieldwork in various weather conditions
o Adaptability and eagerness to learn new techniques and concepts
Candidates should demonstrate a genuine interest in antimicrobial resistance research and its environmental implications. The ideal applicant will show enthusiasm for combining laboratory work with field studies and data analysis to address this critical global health challenge.
*Non-UK applicants must meet the programme’s English language requirement prior to a formal offer being made.
Equality, Diversity, and Inclusion:
We value a diverse research environment and aim to be an inclusive university, where difference is celebrated and respected. We welcome and encourage applications from under-represented groups.
If you have circumstances that you feel we should be aware of that have affected your educational attainment, then please feel free to tell us about it in your application form. The best way to do this is a short paragraph at the end of your personal statement.
Enquiries and Applications:
Formal applications should be submitted via the Red-ALERT CDT online application form prior to the closing date of this advert.
Funding Notes
Candidates may be considered for a NERC Red-ALERT studentship tenable for 3.5 years. Funding covers tuition fees, a stipend (ÂŁ19,237 p/a in 2024/5) and access to a training support budget.